Corticosteroids and glaucoma: How do treatments trigger ocular nerve damage? - A systematic literature review
DOI:
https://doi.org/10.70347/svsthya.v1i3.22Keywords:
Corticosteroids, glaucoma, retinal ganglion cells, eye nerve, comorbidAbstract
Corticosteroids are steroid hormone derivatives produced by the adrenal glands. Corticosteroids in the health sector have been widely utilized as anti-inflammatory agents because of their strong and rapid effects. This study aimed to identify the impact of long-term corticosteroid use on eye damage. This study uses a systematic literature review, which is guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) to the article screening process. The data of this study, in the form of demographic variables, route of administration, steroid type, comorbidities, and patient risk factors, were descriptively analyzed. As a result, 15 of the 22 articles were selected for analysis. Chronic corticosteroid administration may precipitate optic neuropathy, manifesting as glaucoma, which is characterized by progressive structural degeneration of retinal ganglion cells (RGCs) and concomitant visual function deterioration. The locus of primary pathological insult in glaucomatous conditions is the optic nerve head, specifically at the optic disc. This anatomical site is notable for the abrupt 90-degree angular deviation of RGC axons as they transition from the retinal nerve fiber layer to their trajectory within the optic nerve proper. The use of corticosteroids can damage ocular nerve tissue through an increase in intraocular pressure (IOP) beyond 21 mmHg. This increase in IOP is due to changes in the microstructure of the trabeculum webbing, resulting in increased obstruction to the outflow of aqueous humor.
Downloads
References
Alotaibi M, Albaqami F, Alfadli F, Aljuaid A, Albaqami M, Alshehri M, et al. Clinical analysis of steroids induced glaucoma: a systematic review. J Complement Med Res 2022;13:10. https://doi.org/10.5455/jcmr.2022.13.04.03.
Liu J, Arrigg CA. Corticosteroid-induced glaucoma. Albert and Jakobiec’s Principles and practice of ophthalmology, Cham: Springer International Publishing; 2020, p. 1–20. https://doi.org/10.1007/978-3-319-90495-5_183-1.
Singh D, Sharma N, Agarwal R. Prevalence of steroid-induced glaucoma among patients suffering from vernal kerato-conjunctivitis in central India. Indian J Clin Exp Ophthalmol 2022;8:363–7. https://doi.org/10.18231/j.ijceo.2022.074.
Roberti G, Oddone F, Agnifili L, Katsanos A, Michelessi M, Mastropasqua L, et al. Steroid-induced glaucoma: Epidemiology, pathophysiology, and clinical management. Surv Ophthalmol 2020;65:458–72. https://doi.org/10.1016/j.survophthal.2020.01.002.
Savitri IAGW, Adnyana IMDM, Wahyudi IW, Dewi GAPWP, Ariastuti I, Sundari NLPA, et al. Exposure to electromagnetic waves for reducing brain health: A bibliometric analysis. Svāsthya Trends Gen Med Public Health 2024;1:e12. https://doi.org/10.70347/svsthya.v1i1.12.
Rosalia Adriani Malika, Lydia Nuradianti. Bilateral steroid induced glaucoma in a 10-year-old boy. Asian J Health 2023;2:55–9. https://doi.org/10.55561/ajhr.v2i2.97.
Levin AM, Sieck EG. New concepts in steroid glaucoma. Curr Ophthalmol Rep 2023;11:78–82. https://doi.org/10.1007/s40135-023-00316-9.
Jain D, Dangda S, Yadava U, Gupta S. Historical review of steroid-induced glaucoma. J Curr Glaucoma Pract 2010;4:109–13. https://doi.org/10.5005/jp-journals-10008-1079.
Rahayu NK, Emily A. Clinical profile of steroid-induced glaucoma in Bali Mandara Eye Hospital year 2019. Intisari Sains Medis 2021;12:6–8. https://doi.org/10.15562/ism.v12i1.872
Ahmadzadeh A, Kessel L, Schmidt BS, Bach-Holm D. Steroid response after trabeculectomy—a randomized controlled trial comparing dexamethasone to diclofenac eye drops. J Clin Med 2022;11:7365. https://doi.org/10.3390/jcm11247365.
Harvey D, Sugali CK, Mao W. Glucocorticoid-induced ocular hypertension and glaucoma. Clin Ophthal 2024;18:481–505. https://doi.org/10.2147/OPTH.S442749.
Adnyana IMDM. Meta Analisis. In: Akbar H, editor. Biostatistika Epidemiologi. 1st ed., Bandung: CV. Media Sains Indonesia; 2023, p. 185–205.
Paulus AY, Sulaeman, Mayasari AC, Ayu JD, Musniati N, Sari MP, et al. Biostatistika Epidemiologi. 1st ed. Bandung: CV. Media Sains Indonesia; 2023.
Wiyani ZO. Steroid-induced glaucoma and blindness in a case of vernal keratoconjunctivitis: a therapeutic management. Medula 2019;9:545–51. https://doi.org/10.1136/bjophthalmol-2019-313988
Puteri RD, Yusran M. Glaukoma yang diinduksi steroid oculi dextra et sinistra. Med Profess J Lampung 2020;10:155–9. https://juke.kedokteran.unila.ac.id/
Badriyah IN, Irfani I, Rakhmilla LE. Characteristics of childhood steroid-induced glaucoma patients in national eye center, cicendo eye hospital, Bandung, Indonesia from 2007 to 2011. Althea Med J 2015;2:346–351. https://doi.org/10.15850/amj.v2n3.558.
Artini W. Steroid- Induced Glaucoma. Depok: 2010.
van Rijn LJ, Eggink CA, Janssen SF. Circumferential (360°) trabeculotomy for steroid-induced glaucoma in adults. Graefes Arch Clin Exp Ophthalmol 2023;261:1987–94. https://doi.org/10.1007/s00417-023-06012-5.
Bachman W, Maddala R, Chakraborty A, Eldawy C, Skiba NP, Rao P V. Glucocorticoids preferentially influence expression of nucleoskeletal actin network and cell adhesive proteins in human trabecular meshwork cells. Front Cell Dev Biol 2022;10. https://doi.org/10.3389/fcell.2022.886754.
Pandav S, Kaur S, Kaushik S, Phulke S. Steroid-induced glaucoma: an avoidable irreversible blindness. J Curr Glaucoma Pract 2017;11:67–72. https://doi.org/10.5005/jp-journals-10028-1226.
Nupur S, Dheerendra S, Rahul A. Prevalence of steroid-induced glaucoma among patients suffering from vernal kerato-conjunctivitis in central India. Indian J Clin Exp Ophthalmol 2022;2022:17528. https://doi.org/2395-1451.
Mahendra BI, Gustianty E, Rifada RM. Karakteristik klinis glaukoma primer sudut tertutup di pusat mata nasional rumah sakit mata Cicendo pada tahun 2020. J Kedokteran dan Kesehatan: Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya 2022;9:235–44. https://doi.org/10.32539/JKK.V9I2.16963.
Artini W, Dame. Glaucoma caused blindness with its characteristic in Cipto Mangunkusumo Hospital. J Oftalmologi Indonesia 2011;7:189–93. https://journal.unair.ac.id/download-fullpapers-JOI%20Vol%207%20No%205%20Juni%202011%20(Widya%20A).pdf
Senthil S, Thakur M, Rao HL, Mohamed A, Jonnadula GB, Sangwan V, et al. Steroid-induced glaucoma and blindness in vernal keratoconjunctivitis. Br J Ophthalmol 2020;104:265–9. https://doi.org/10.1136/bjophthalmol-2019-313988.
Dhamecha DrY, Patel DrR, Kunal Dr. Comparative study of adverse drug reactions of corticosteroids. Int J Dermatol Venereology Leprosy Sci 2022;5:06–10. https://doi.org/10.33545/26649411.2022.v5.i1a.104.
Masloman AH, Kasih F. Steroid induced glaucoma and primary angle closure glaucoma: a case report of mixed mechanism glaucoma. Ophthalmologica Indonesiana 2024;49. https://doi.org/10.35749/kgps5q05.
Suparta PGYDW, Suryaningrum IGAR, Kusumadjaja IMA. Bilateral glaucoma drainage device (GDD) implantation in steroid induced glaucoma. Intisari Sains Medis 2023;14:1053–8. https://doi.org/10.15562/ism.v14i3.1884.
Husna I, Ramatillah DL, Anggraeni YD. Evaluation of the side effects of corticosteroid eye drops use in postoperative patients at the Jakarta Eye Hospital pharmacy installation. Arch Pharm 2019;1:106,152. https://doi.org/10.47007/ap.v1i2.2768
Mehta JS, Chen W-L, Cheng ACK, Cung LX, Dualan IJ, Kekunnaya R, et al. Diagnosis, management, and treatment of vernal keratoconjunctivitis in Asia: recommendations from the management of vernal keratoconjunctivitis in Asia Expert Working Group. Front Med (Lausanne) 2022;9:882240. https://doi.org/10.3389/fmed.2022.882240.
Teo BHK, Au Eong JTW, Au Eong KG. Steroid-induced glaucoma: an avoidable cause of irreversible blindness. BMJ Case Rep 2023;16:e254709. https://doi.org/10.1136/bcr-2023-254709.
Gauthier AC, Liu J. Neurodegeneration and neuroprotection in glaucoma. Yale J Biol Med 2016;89:73–9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797839/
Zhou L, Zhan W, Wei X. Clinical pharmacology and pharmacogenetics of prostaglandin analogues in glaucoma. Front Pharmacol 2022;13:1015338. https://doi.org/10.3389/fphar.2022.1015338.
Pillai MR, Balasubramaniam N. Commentary: Surgical outcomes in uveitic glaucoma and steroid-induced glaucoma in children: Between the two evils. Indian J Ophthalmol 2022;70:4225–7. https://doi.org/10.4103/ijo.IJO_2255_22.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 I Gede Satya Wijaya Putra, I Made Dwi Mertha Adnyana, I Wayan Wahyudi, Anak Agung Komang Suardana, Ni Komang Rina Indrayanti, Sang Kompyang Yudistira Eddy Prabowo, I Gede Panduyasa, Dewa Ayu Widyantari, Desak Gede Dwi Agustini, Ni Made Ayu Suwandani
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
This license enables reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
